Simultaneous measurements of neutron star masses and radii can be used to constrain deviations from general relativity (GR) as was recently demonstrated for the spontaneous scalarization model of Damour and Esposito-Farese (DEF). Here, we investigate the general applicability of the same procedure beyond this single example. We first show that a simple variation of the DEF model renders the same mass-radius measurements ineffective for obtaining constraints. On the other hand, a recently popular and distinct model of scalarization that arises in scalar-Gauss-Bonnet theory can be constrained similarly to the original DEF model, albeit due to a slightly different underlying mechanism. These establish that using the mass-radius data can potentially constrain various theories of gravity, but the method also has limitations.